Methods: JTG was analyzed using Nano LC-MS/MS and orally administered in CIA rats for 6 weeks. Inspired by those, the purpose of this study was to investigate whether JTG also had an effect on relieving rheumatoid arthritis in collagen-induced arthritic (CIA) rats and explore potential mechanism from the perspective of serum metabolic profile changes. However, as a precious material of traditional Chinese medicine (TCM), TB has been mainly understood and used in TCM to relieve osteoporosis, rheumatoid arthritis and bone injury. The drug is composed of bionic TB powder, in which peptides and proteins are primarily enriched from other bone extracts. Purpose: Jintiange capsule (JTG), an approved drug developed as a substitute for tiger bone (TB), has been clinically applied for osteoporosis therapy since 2003.

*These authors contributed equally to this workĬorrespondence: Qiaoyan Zhang Luping Qin Tel +86 571-6176 8519Įmail Xiaoyan Wang, 1, * Yi Shen, 1, * Xinying Zhuang, 1 Na Wang, 2 Qi Zhang, 1 Lulin Zhu, 1 Yuling Liu, 1 Xinyu Lu, 1 Luping Qin, 1 Qiaoyan Zhang 1ġSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People’s Republic of China 2Ginwa Enterprise (Group) INC, Xi’an, 710069, People’s Republic of China

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